The Direct Adrenergic Drugs Are Mostly Stereoselective for the Adrenergic Receptors

Authors

  • Rezk R. Ayyad Pharmaceutical Medicinal Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt
  • Ahmed M. Mansour Pharmacology and Toxicology Department, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt
  • Ahmed M. Nejm Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt
  • Yasser Abdel Allem Hassan Pharmaceutics and Pharmaceutical Technology Department, Faculty of Pharmacy, Delta University for Science and Technology, Gamasa, Addaqahlya, Egypt
  • Ahmed R. Ayyad Faculty of Medicine, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan

Keywords:

adrenaline, nor-adrenaline, salbutamol, terbutaline, dipivefrine, ephedrine, adrenergic receptors, stereoselectivity

Abstract

The adrenaline, nor-adrenaline, and its analogs for example terbutaline, salbutamol, dipivefrin, ephedrine, phenylpropanolamine, phenylephrine… etc.
These compounds are characterized by containing chiral carbon which is surrounded by 4 different groups and makes these compounds able to rotate to the right or left which binds with adrenergic receptors in a specific position to make stereoselectivity between compounds and adrenergic receptors, this stereoselectivity increases the affinity of drug to the receptor and mostly increase the activity.

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Published

2025-02-27

How to Cite

Rezk R. Ayyad, Ahmed M. Mansour, Ahmed M. Nejm, Yasser Abdel Allem Hassan, & Ahmed R. Ayyad. (2025). The Direct Adrenergic Drugs Are Mostly Stereoselective for the Adrenergic Receptors. ournal of rogress in ngineering and hysical cience, 4(1), 8–10. etrieved from https://www.pioneerpublisher.com/jpeps/article/view/1207

Issue

Vol. 4 No. 1 (2025): February

Section

Articles