The Protective Role of GRP78 Against Blue Light Hazard

Authors

  • Xinmeng Li School of Public Health, Guangdong Pharmaceutical University, Guangdong, China
  • Yuanyuan Tang School of Public Health, Guangdong Pharmaceutical University, Guangdong, China
  • Zhiye Mai School of Public Health, Guangdong Pharmaceutical University, Guangdong, China
  • Enyi Li School of Public Health, Guangdong Pharmaceutical University, Guangdong, China
  • Zhaoying Gan School of Public Health, Guangdong Pharmaceutical University, Guangdong, China

Keywords:

blue light, GRP78, retinal pigment epithelium, lipofuscin, oxidative stress, cancer cells

Abstract

GRP78, a pivotal chaperone protein residing in the endoplasmic reticulum, effectively mitigates cellular damage inflicted by blue light. It exerts this protective function through multiple mechanisms, including the suppression of blue light-induced oxidative stress, facilitation of protein repair damaged by blue light, and inhibition of blue light-mediated apoptosis. GRP78’s pivotal role in defending against blue light damage underscores its potential as a novel target for developing effective blue light protection strategies. Future endeavors delving into the mechanisms and functions of GRP78 may yield efficient drugs and preventive measures against blue light hazards, thereby safeguarding human health.

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Published

2024-09-10

Issue

Vol. 3 No. 3 (2024): September

Section

Articles