Stereo Selectivity of Histaminic Receptors Play an Important Role of Anti-histaminic Activity

Authors

  • Rezk R. Ayyad Pharmaceutical Medicinal Chemistry Department, Faculty of Pharmacy, ALAZHAR University, Cairo, Egypt
  • Ahmed M. Mansour Pharmacology and Toxicology Department, Faculty of Pharmacy, ALAZHAR University, Cairo, Egypt
  • Ahmed M. Nejm Pharmaceutical Medicinal Chemistry Department, Faculty of Pharmacy, ALAZHAR University, Cairo, Egypt
  • Yasser Abdel Allem Hassan Pharmaceutics and Pharmaceutical Technology Department, Faculty of Pharmacy, Delta
  • Ahmed R. Ayyad Faculty of Medicine, Asfendiyarov, Almaty, Kazakh, National Medical University (KazNMU)

Keywords:

Histaminic receptors, H1, H2, H3 and H4, chiral carbon, lipid solubility, anti- histaminic activity, H1 antagonists and H2 antagonists

Abstract

The histamine is a natural compound derived from histidine and amino acid which act on different histaminic receptors (H1, H2, H3 and H4), each receptor combined with histamine and give the different actions especially H1 and H2 receptors.

The action of each depends on the specificity of the receptors, e.g., the compounds which act on H1 receptor are similar to each other but different than the compounds which act on H2 receptor (due to the difference between two receptors from the area and stereo of the receptors).

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Published

2024-01-29

Issue

Vol. 3 No. 1 (2024): March

Section

Articles