Retinol Metabolism and Neuroactive Ligand-Receptor Interactions Are Key Pathways Involved in Skeletal Muscle Stem Cells (MuSCs) Aging

Abstract

Sarcopenia is characterized by the loss of muscle function and mass as one ages. Muscle stem cells (MuSCs) play a central role to this process, as it is responsible for muscle repair and regeneration. The progressive loss of function in aging skeletal muscle stem cells is thought to be highly influential. This study aims to analyze RNASeq data obtained from young and old skeletal muscle stem cells of Mus musculus and uncover differentially expressed genes between the two groups. These differentially expressed genes were then analyzed to uncover key pathways crucial to the process of MuSC aging. This includes retinol metabolism and neuroactive ligand-receptor interactions.