Hydrophobicity, Transport and Target Sites of Action Are Important for the Activity of Many Drugs

Authors

  • Rezk R. Ayyad Pharmaceutical Medicinal Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt
  • Ahmed M. Nejm Pharmaceutical Medicinal Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt
  • Yasser H. Abdelaleem Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Delta University, Aldaquahlia, Egypt
  • Ahmed R. Ayyad Asfendiyarov Kazakh National Medical University (KazNMU), Almaty, Kazakhastan

Keywords:

hydrophobicity, transport of drug, tissue binding drug, lipid solubility, Blood Brain Barrier (BBB)

Abstract

The Hydrophobicity mean the compounds which insoluble in water i.e., hate the water (not love the water). May be these compounds are lipid soluble, but not actually. This means these compounds may across the cell membrane of the cell. This transport of compounds through, simple diffusion, passive transport (active transport), transport by carrier (amino acids carrier), pinocytosis. And the binding of drugs with tissue (may be receptors or tissue reservoir as (fatty tissue and lipid soluble vitamins) and the carbohydrates (glucose convert to glycogen in the liver).

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Published

2023-07-19

Issue

Vol. 2 No. 3 (2023): September

Section

Articles