Progress in the Research of Reflux Nephropathy

Abstract

Reflux nephropathy (RN) is a renal disease caused by Vesicoureteral Reflux (VUR) and Intrarenal Reflux (IRR), resulting in renal cortical scar (localized atrophy) and focal glomerulosclerosis. RN is one of the important causes of end-stage renal diseases (ESRD). The most basic pathological feature of RN is kidney scarring. Common clinical manifestations are persistent or recurrent urinary tract infection, albuminuria, hypertension, nocturia, polyuria, lumbago, urinary calculi, etc. Due to the hidden condition of RN, doctors in various departments, especially in pediatrics, nephrology and urology, must strengthen their understanding and understanding of this disease, so as to facilitate the early detection and diagnosis of this disease. Correct conservative treatment of Western medicine, surgical treatment when necessary, and reasonable integrated treatment of Chinese and Western medicine are of great significance for the prevention and treatment of the progression from RN to ESRD.