Metabolism of Some Drugs Which Contain Carbonyl Group Make It Stereogenic Drug by Reductase Enzyme

Abstract

The metabolism is biotransformation refers to the processes by which the body chemically alters drugs, transforming them into different chemical compounds called metabolites. One of these processes is reduction of the drugs by reductase enzyme which add hydrogen to the compound, e.g. acetohexamide (oral hypoglycemic drug), loxoprofen (analgesic), haloperidol (antipsychotic drug), oxisuran (immunosuppressive agent), bupropion (antidepressant drug). All of these drugs contain a carbonyl group, which is reduced by reductase enzyme and converted into a chiral carbon, which makes the drug stereogenic.