Esterification of Many Drugs Causes Its Prolonged Action Due to Increase Lipid Solubility and Store in Fatty Tissues

Authors

  • Rezk R. Ayyad Pharmaceutical Medicinal Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt
  • Ahmed M. Mansour Pharmacology and Toxicology Department, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt
  • Ahmed M. Nejm Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt
  • Yasser Abdel Allem Hassan Pharmaceutics and Pharmaceutical Technology Department, Faculty of Pharmacy, Delta
  • Ahmed R. Ayyad Faculty of Medicine, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan

Keywords:

esterification, acid, alcohol, phenothiazine, progesterone, testosterone, lipid solubility, hydrolysis

Abstract

The esterification process is a reaction between alcohol and acid which increases the resistance to metabolism, increases lipid solubility, and takes time to liberate the active constituent either alcohol or acid. Fluphenazine is an antipsychotic drug that is in the form of decanoate which is prolonged in its action making it take 1 month. Nandrolone decanoate, progesterone acetate, propionate and cypionate, also benzathine and penicillin procaine.

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Published

2025-03-31

Issue

Vol. 4 No. 2 (2025): March

Section

Articles